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Life Extension May Add Just Bad Time
【科学60秒】长寿不等于健康幸福
Living longer doesn’t necessarily mean living better. That’s the lesson from the tiny roundworm called C. elegans, long a workhorse in basic biology lab work. The research is in the Proceedings of the National Academy of Sciences. [Ankita Bansal et al, Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants]
活得时间变长了并不等同于活的更好了。这是我们从对线虫也就是C.elegans的研究中得到的经验，它可是生物学实验室中有很长工作经验的员工了哦。相关研究已发表在《国家科学研究进展》杂志上。
In the study, thousands of normal C. elegans competed against strains that live days or weeks longer than their brethren, because of factors like genetic mutations or very low-calorie diets.
该研究项目，使用了许多正常线虫，以及采用遗传突变或者低卡路里饮食造成才生命更长几天或者几周的同胞兄弟线虫模型 进行研究对比。
But a battery of tests to see how the all older worms moved or responded to stress revealed some hard truths: increased life span did not usually come with a prolonged period of health and strength. Indeed, the “good times” for each of the worms was roughly the same, regardless of their overall life span. In other words, the longer-living worms spent a greater proportion of their lives in a diminished state—with less mobility and stress resistance.
为了看看所有这些年级大的线虫移动或者应对压力的反应情况研究人员们进行了许多研究测试 ，然后得出了一些强有力的结论：生命时间延长并不等于是通常意义上认为的更加健康和强壮这些原因造成的。确实，每条线虫的美好时光阶段都差不多，不同的只有它们整个寿命。换句话说，寿命长的线虫也拥有更长的衰老阶段——活力和抗压能力都不是很高。
Aging worms are not aging humans. But if the findings do extend to people, then life-extension efforts, such as calorie restriction, may not shake out to a better old age, just more years of frailty. With associated healthcare cost increases and quality of life decreases. The researchers suggest that it’s time to start thinking about what they call “healthspan”—and maximizing “healthspan,” rather than just tacking on years of poor quality.
这些上了年纪的线虫并不是上了年纪的人类。但是 如果这些研究的结论确实能扩展应用到人类身上的话，我们为了延长生命所作出一切努力，比如说，低卡路里饮食，也许并不能彻底转变老化的问题，只不过虚弱的时间更长罢了。同时还有健康医疗支出的上升以及生活质量的下降。那些研究人员们建议是时候让我们来思考一下他们常说的健康时段——以及最大化的健康时段，而不仅仅是再多过几年悲惨的日子呢。
